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A new chlorinated phenylpyrrole antibiotic produced by the antifungal bacterium Pseudomonas cepacia

Author:
Roitman, J.N., Mahoney, N.E., Janisiewicz, W.J., Benson, M.
Source:
Journal of agricultural and food chemistry 1990 v.38 no.2 pp. 538-541
ISSN:
0021-8561
Subject:
Burkholderia cepacia, biological control, decay fungi, antifungal properties
Abstract:
A group of chlorinated phenylpyrrole derivatives was isolated from a strain of Pseudomonas cepacia collected from apple leaves during a screening program designed to detect agents for biological control of fruit spoilage fungi. One of these substances, 2,3-dichloro-4-(2-amino-3-chlorophenyl)pyrrole, has not been previously reported. In vitro testing showed that all four of the phenylpyrroles had antifungal activity toward several fruit pathogens. The new phenylpyrrole showed fungal inhibitory effects on Golden Delicious apples inoculated with conidia of pathogenic organisms. An unrelated but known compound, 2-(2-heptenyl)-3-methyl-4(1H)-quinolone, was also isolated.
Agid:
1375608