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A pilot study comparing a protocol using intermittent administration of glargine and regular insulin to a continuous rate infusion of regular insulin in cats with naturally occurring diabetic ketoacidosis
- Gallagher, Brandi R., Mahony, Orla M., Rozanski, Elizabeth A., Buob, Sibylle, Freeman, Lisa M.
- Journal of veterinary emergency and critical care 2015 v.25 no.2 pp. 234-239
- appetite, bicarbonates, cats, hyperglycemia, insulin, ketonemia, ketosis, pH, randomized clinical trials, veterinary medicine
- OBJECTIVE: The goal of this pilot study was to compare regular insulin administered by continuous rate infusion (CRI) to an approach using insulin glargine and regular insulin administered intermittently. DESIGN: Prospective randomized clinical trial. SETTING: University teaching hospital. ANIMALS: Sixteen cats with diabetic ketoacidosis (DKA). INTERVENTIONS: Cats with DKA were randomized to either low‐dose regular insulin CRI (CRI group; n = 8) or intermittent short‐ and long‐acting insulin injections (subcutaneous [SC] glargine plus intramuscular [IM] regular insulin; SC/IM group; n = 8). MEASUREMENTS AND MAIN RESULTS: Time of normalization of pH, bicarbonate, hyperglycemia, ketonemia, and appetite, as well as duration of hospitalization were recorded. Eleven of 16 cats (59%) survived to discharge, with no difference in survival between groups (P = 0.99). Times of resolution of hyperglycemia (P = 0.02) and ketonemia (P = 0.04), and normalization of pH (P = 0.04), and bicarbonate (P = 0.03) were significantly shorter in the SC/IM group. Cats in the SC/IM group also had a significantly shorter duration of hospitalization (SC/IM: median = 54 hr [range, 19–118 hr]; CRI: median = 111 hr [range, 58–271 hr]; P = 0.04). Time of first meal was not significantly different between groups. CONCLUSIONS: Although further research is required, an approach using intermittent short‐ and long‐acting insulin injections appeared to be an effective option for treatment of DKA in cats.