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Modeling DNA supercoils and knots with B-spline functions

Author:
Hao, M.H., Olson, W.K.
Source:
Biopolymers 1989 v.28 no.4 pp. 873-900
ISSN:
0006-3525
Subject:
protein secondary structure, mathematical models, DNA, DNA conformation
Abstract:
A method is offered to model the complex trajectories of closed circular DNA supercoils and knots. The trajectories are approximated by polygons and analytical expressions of the curves are generated from the polygons with B-spline functions. The resulting curves are used to evaluate the writhe and elastic energy of a series of interrelated supercoils and to generate detailed atomic models of the deformed double helix.
Agid:
1383679