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Use of oral buprenorphine ('buprenorphine jello') for postoperative analgesia in rats-a clinical trial

Flecknell, P. A., Roughan, J. V., Stewart, R.
Laboratory animals 1999 v.33 no.2 pp. 169-174
rats, analgesics, postoperative care, dosage, drug formulations, feed intake, oral administration, body weight, laparotomy, stomach, weight
Buprenorphine (0.l, 0.2, 0.3 or 0.4 mg/kg) in a flavoured gelatin base was administered preoperatively to rats undergoing a flank laparotomy. A control group of animals underwent surgery and received only flavoured gelatin. Body weight loss was significantly greater in the group which received no analgesia than in any of the analgesic-treated groups (P < 0.01). Food consumption was reduced significantly in all groups except in those animals which received 0.3 mg/kg buprenorphine. Water consumption was significantly reduced in the control (no analgesia) group (P < 0.001), but was not significantly depressed in the analgesic-treated groups (P > 0.05). Between-group comparisons did not show any significant difference between the different dose rates of analgesia used on either the change in body weight or the reduction in food or water consumption. The results of this study support the use of buprenorphine jelly for post-surgical analgesia in rats. This route of delivery is easy to use, and causes a minimum of stress to the rats.