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Biotransformation of malachite green by the fungus Cunninghamella elegans

Author:
Cha, C.J., Doerge, D.R., Cerniglia, C.E.
Source:
Applied and environmental microbiology 2001 v.67 no.9 pp. 4358-4360
ISSN:
0099-2240
Subject:
metabolism, cytochrome P-450, Cunninghamella elegans, biodegradation, malachite green
Abstract:
The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 micromol h(-1) (mg of cells)-1. Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions.
Agid:
1409261