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Increase in Activity During Calorie Restriction Requires Sirt1
- Chen, Danica, Steele, Andrew D., Lindquist, Susan, Guarente, Leonard
- Science 2005 v.310 no.5754 pp. 1641
- low calorie diet, esterases, knockout mutants, physical activity, food intake, mice
- Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.