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Effects of on-arrival versus delayed modified live virus vaccination on health, performance, and serum infectious bovine rhinotracheitis titers of newly received beef calves

Richeson, J.T., Beck, P.A., Gadberry, M.S., Gunter, S.A., Hess, T.W., Hubbell, D.S. III., Jones, C.
Journal of animal science 2008 v.86 no.4 pp. 999-1005
vaccination, blood chemistry, liveweight gain, infectious bovine rhinotracheitis, seroconversion, temporal variation, vertebrate viruses, feeder cattle, body weight, morbidity, weaning, animal transport, immune response, calves, Bovine alphaherpesvirus 1, live vaccines
Stress commonly associated with weaning, marketing, and shipment of feeder cattle can temporarily compromise immune function, thereby reducing the effective response to vaccination intended to control bovine respiratory disease (BRD). Two vaccination timing treatments were used to evaluate the effect of timing of a multivalent modified live virus (MLV) BRD vaccine on health, performance, and infectious bovine rhinotracheitis (IBR) antibody titers of newly received stocker cattle. Crossbred bull and steer calves (n = 528) were weighed (197 ± 2.4 kg) and randomly assigned to MLV vaccination treatment: 1) MLV vaccination upon arrival (AMLV), or 2) delayed (14 d) MLV vaccination (DMLV). All cattle were processed similarly according to routine procedures, with the exception of the initial MLV vaccination timing. Subsequently, BW were recorded on d 14, 28, and 42. Blood samples were collected on d 0, 14, 28, and 42 to determine serum IBR titers, and comparisons were made between treatments on a receiving-day basis and an equivalent postvaccination day basis. Daily BW gains were greater (P = 0.15). Morbidity rates for BRD were high for both AMLV and DMLV (71.5 and 63.5%, respectively) and did not differ (P = 0.12). Positive IBR titer seroconversion was greater (P <= 0.03) for DMLV calves on d 42 of the study, and for the 28- and 42-d equivalent postvaccination basis. Delaying vaccination by 14 d may increase ADG during the receiving period compared with AMLV, and seroconversion to IBR was greater in DMLV calves, indicating a possible improvement in acquired immune response when MLV vaccination is delayed.