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Dietary Oat β-Glucan Reduces Peak Net Glucose Flux and Insulin Production and Modulates Plasma Incretin in Portal-Vein Catheterized Grower Pigs

Author:
Hooda, Seema, Matte, J. Jacques, Vasanthan, Thavaratnam, Zijlstra, Ruurd T.
Source:
Journal of nutrition 2010 v.140 no.9 pp. 1564-1569
ISSN:
0022-3166
Subject:
dietary nutrient sources, oats, beta-glucans, glucose, insulin, secretin, portal vein, swine, animal models, experimental diets, blood sampling, dietary supplements, glucagon-like peptides
Abstract:
Net glucose and SCFA flux and insulin secretion into the portal vein might be associated with the incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Our objectives were to clarify this association and study the impact of 2 doses of dietary oat β-glucan on the variables. Three 35-kg portal vein-catheterized pigs were fed 3 diets containing 0, 3, or 6% oat β-glucan concentrate (BG0, BG3, and BG6) for 7 d in a repeated 3 times 3 Latin square. On d 7, blood was sampled for 12 h postprandially. Net glucose flux and apparent hormone production were calculated from plasma portal-arterial differences times flow. Postprandially, pigs fed BG6 had lower (P lt 0.05) portal glucose at 15, 30, and 45 min and a lower (P lt 0.05) net glucose flux during the first hour. Pigs fed BG6 tended to have lower (P lt 0.10) portal C-peptide without lowering insulin, indicating that pigs fed BG6 had lower actual insulin release combined with a higher prehepatic retention of insulin. Pigs fed BG6 had lower (P lt 0.05) portal GIP and GLP-1, which in turn were correlated (R² = 0.81 and 0.88, respectively; P lt 0.01) with portal glucose. Pigs fed BG3 and BG6 had a higher (P lt 0.05) net SCFA flux than pigs fed BG0, indicating increased fermentation. In conclusion, dietary supplementation of 6% oat β-glucan concentrate decreased net glucose flux, increased net SCFA flux, and decreased peak apparent insulin production, changes that were associated with GIP and GLP-1 mediation.
Agid:
1461337