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The {szligbeta}-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel

Author:
Chang, Q., Hoefs, S., Kemp, A. W. van der, Topala, C. N., Bindels, R. J., Hoenderop, J. G.
Source:
Science 2005 v.310 no.5747 pp. 490-493
ISSN:
0036-8075
Subject:
blood, calcium, calcium channels, hydrolysis, kidneys, mammals, oligosaccharides, permeability, plasma membrane
Abstract:
Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a {szligbeta}-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.
Agid:
1530835