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Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2
- Kim, Sangwon F., Huri, Daniel A., Snyder, Solomon H.
- Science 2005 v.310 no.5756 pp. 1966-1970
- anti-inflammatory agents, catalytic activity, inducible nitric oxide synthase, prostaglandin synthase
- Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.