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Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis
- Pan, Haiyun, Zhou, Rui, Louie, Gordon V., Mëühlemann, Joëlle K., Bomati, Erin K., Bowman, Marianne E., Dudareva, Natalia, Dixon, Richard A., Noel, Joseph P., Wang, Xiaoqiang
- The plant cell 2014 v.26 no.9 pp. 3709-3727
- biosynthesis, cinnamoyl-CoA reductase, engineering, enzyme activity, lignin, substrate specificity
- The enzymes cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase participate in the generation of building blocks for plant lignin-polymers. Their structures reported here shed light on the mechanisms of enzyme activity and regulation and on the determinants of substrate specificity. These findings may ultimately aid in the rational engineering of lignin composition in plants.