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Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis

Author:
Pan, Haiyun, Zhou, Rui, Louie, Gordon V., Mëühlemann, Joëlle K., Bomati, Erin K., Bowman, Marianne E., Dudareva, Natalia, Dixon, Richard A., Noel, Joseph P., Wang, Xiaoqiang
Source:
The plant cell 2014 v.26 no.9 pp. 3709-3727
ISSN:
1040-4651
Subject:
biosynthesis, cinnamoyl-CoA reductase, engineering, enzyme activity, lignin, substrate specificity
Abstract:
The enzymes cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase participate in the generation of building blocks for plant lignin-polymers. Their structures reported here shed light on the mechanisms of enzyme activity and regulation and on the determinants of substrate specificity. These findings may ultimately aid in the rational engineering of lignin composition in plants.
Agid:
1718307