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Arabidopsis thaliana RNase H2 Deficiency Counteracts the Needs for the WEE1 Checkpoint Kinase but Triggers Genome Instability
- Kalhorzadeh, Pooneh, Hu, Zhubing, Cools, Toon, Amiard, Simon, Willing, Eva-Maria, De Winne, Nancy, Gevaert, Kris, De Jaeger, Geert, Schneeberger, Korbinian, White, Charles I., De Veylder, Lieven
- The plant cell 2014 v.26 no.9 pp. 3680-3692
- Arabidopsis thaliana, DNA, excision, genome, hydrogen, phenotype, ribonucleases, ribonucleotides
- Absence of the RNAse H2 complex, mediating the excision of ribonucleotides from DNA, was found to overcome the growth inhibitory phenotype of plants lacking a functional replication checkpoint because of tolerating the substitution of deoxynucleotides with ribonucleotides. This substitution, however, results in replication errors, demonstrating the need of RNase H2 activity for genome stability.