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How Vacuolar Sorting Receptor Proteins Interact with Their Cargo Proteins: Crystal Structures of Apo and Cargo-Bound Forms of the Protease-Associated Domain from an Arabidopsis Vacuolar Sorting Receptor

Author:
Luo, Fang, Fong, Yu Hang, Zeng, Yonglun, Shen, Jinbo, Jiang, Liwen, Wong, Kam-Bo
Source:
The plant cell 2014 v.26 no.9 pp. 3693-3708
ISSN:
1040-4651
Subject:
Arabidopsis, crystal structure, mutagenesis, proteins, vacuoles
Abstract:
This work explores how vacuolar sorting receptor (VSR) recognizes sequence-specific information on cargo proteins for targeting to the vacuole. Elucidation of the structures of the protease-associated domain of a VSR with and without its cognate cargo peptide, along with mutagenesis and functional studies, provides insights into how VSR recognizes its cargo proteins.
Agid:
1718321