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LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

Author:
Li, Ying, Chen, Rui, Zhou, Qian, Xu, Zhisheng, Li, Chao, Wang, Shuai, Mao, Aiping, Zhang, Xiaodong, He, Weiwu, Shu, Hong-Bing
Source:
Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.29 pp. 11770-11775
ISSN:
0027-8424
Subject:
DNA, DNA viruses, RNA, immune response, interferon-beta, peroxisomes, receptors
Abstract:
Recognition of viral nucleic acids by pattern recognition receptors initiates type I IFN induction and innate antiviral immune response. Here we show that LSm14A, a member of the LSm family involved in RNA processing in the processing bodies, binds to synthetic or viral RNA and DNA and mediates IRF3 activation and IFN-β induction. Knockdown of LSm14A inhibits cytosolic RNA- and DNA-trigger type I IFN production and cellular antiviral response. Moreover, LSm14A is essential for early-phase induction of IFN-β after either RNA or DNA virus infection. We further found that LSm14A-mediated IFN-β induction requires RIG-I–VISA or MITA after RNA or DNA virus infection, respectively, and viral infection causes translocation of LSm14A to peroxisomes, where RIG-I, VISA, and MITA are located. These findings suggest that LSm14A is a sensor for both viral RNA and DNA and plays an important role in initiating IFN-β induction in the early phase of viral infection.
Agid:
1721717