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Pathological crystallization of human immunoglobulins
- Wang, Ying, Lomakin, Aleksey, Hideshima, Teru, Laubach, Jacob P., Ogun, Olutayo, Richardson, Paul G., Munshi, Nikhil C., Anderson, Kenneth C., Benedek, George B.
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.33 pp. 13359-13361
- crystallization, crystals, drug formulations, humans, immune response, immunoglobulin G, myeloma, patients, solubility
- Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.