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Lipid Peroxidation in Nicotinamide-Deficient and Nicotinamide-Supplemented Rats
- Melo, Sandra Soares, Meirelles, Mônica S., Jordão Jr, Alceu Afonso, Vannucchi, Helio
- International journal for vitamin and nutrition research 2000 v.70 no.6 pp. 321-323
- rats, animal models, lipid peroxidation, nicotinamide, vitamin deficiencies, vitamin supplements, oxidation, biomarkers, inhibitors, vitamin E, glutathione, urine, excretion
- Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione. Urinary N-methylnicotinamide excretion was much more marked in the supplemented group, whereas the difference between deficient and control animals was non-significant.