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A Pseudorabies Virus Mutant with Deletions in the Latency and Early Protein O Genes: Replication, Virulence, and Immunity in Neonatal Piglets
- Wesley, Ronald D., Cheung, Andrew K.
- piglets, Suid herpesvirus 1, genes, virulence, virus replication, antibody formation
- The pathogenicity of a double mutant of pseudorabies virus (PRV) with deletions in the latency gene and the early protein O gene was examined. In comparison to the parent Indiana-Funkhauser virus, the ability of this mutant to replicate and to cause disease in piglets is greatly reduced. At an infection dose that caused no clinical signs in 5-day-old neonatal piglets, this mutant was capable of eliciting solid protective immunity against a lethal PRV challenge. Thus, the double-gene deletion attenuates PRV but does not affect its immunogenicity. These features may be desirable for inclusion into future PRV vaccines.