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Constitutive activation of a CC-NB-LRR protein alters morphogenesis through the cytokinin pathway in Arabidopsis

Author:
Igari, Kadunari, Endo, Sachiko, Hibara, Ken-ichiro, Aida, Mitsuhiro, Sakakibara, Hitoshi, Kawasaki, Tsutomu, Tasaka, Masao
Source:
Plant journal 2008 v.55 no.1 pp. 14-27
ISSN:
0960-7412
Subject:
Arabidopsis, cytokinins, disease resistance, gene expression regulation, genes, morphogenesis, mutants, mutation, pathogens, proteins, salicylic acid
Abstract:
Possible links between plant defense responses and morphogenesis have been postulated, but their molecular nature remains unknown. Here, we introduce the Arabidopsis semi-dominant mutant uni-1D with morphological defects. UNI encodes a coiled-coil nucleotide-binding leucine-rich-repeat protein that belongs to the disease resistance (R) protein family involved in pathogen recognition. The uni-1D mutation causes the constitutive activation of the protein, which is stabilized by the RAR1 function in a similar way as in other R proteins. The uni-1D mutation induces the upregulation of the Pathogenesis-related gene via the accumulation of salicylic acid, and evokes some of the morphological defects through the accumulation of cytokinin. The rin4 knock-down mutation, which causes the constitutive activation of two R proteins, RPS2 and RPM1, induces an upregulation of cytokinin-responsive genes and morphological defects similar to the uni-1D mutation, indicating that the constitutive activation of some R proteins alters morphogenesis through the cytokinin pathway. From these data, we propose that the modification of the cytokinin pathway might be involved in some R protein-mediated responses.
Agid:
2056113