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Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors

Author:
Bonardi, Vera, Tang, Saijun, Stallmann, Anna, Roberts, Melinda, Cherkis, Karen, Dangl, Jeffery L.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.39 pp. 16463-16468
ISSN:
0027-8424
Subject:
Arabidopsis, animals, immune response, microbial proteins, pathogens, receptors, salicylic acid, virulence
Abstract:
Plants and animals deploy intracellular immune receptors that perceive specific pathogen effector proteins and microbial products delivered into the host cell. We demonstrate that the ADR1 family of Arabidopsis nucleotide-binding leucine-rich repeat (NB-LRR) receptors regulates accumulation of the defense hormone salicylic acid during three different types of immune response: (i) ADRs are required as "helper NB-LRRs" to transduce signals downstream of specific NB-LRR receptor activation during effector-triggered immunity; (ii) ADRs are required for basal defense against virulent pathogens; and (iii) ADRs regulate microbial-associated molecular pattern-dependent salicylic acid accumulation induced by infection with a disarmed pathogen. Remarkably, these functions do not require an intact P-loop motif for at least one ADR1 family member. Our results suggest that some NB-LRR proteins can serve additional functions beyond canonical, P-loop–dependent activation by specific virulence effectors, extending analogies between intracellular innate immune receptor function from plants and animals.
Agid:
213985