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Post-transcriptional global regulation by CsrA in bacteria

Author:
Timmermans, Johan, Van Melderen, Laurence
Source:
Cellular and molecular life sciences 2010 v.67 no.17 pp. 2897-2908
ISSN:
1420-682X
Subject:
bacteria, biofilm, carbon, gene expression, genes, messenger RNA, metabolism, translation (genetics)
Abstract:
Global regulation allows bacteria to rapidly modulate the expression of a large variety of unrelated genes in response to environmental changes. Global regulators act at different levels of gene expression. This review focuses on CsrA, a post-transcriptional regulator that affects translation of its gene targets by binding mRNAs. CsrA controls a large variety of physiological processes such as central carbon metabolism, motility and biofilm formation. The activity of CsrA is itself tightly regulated by the CsrB and CsrC small RNAs and the BarA-UvrY two-component system.
Agid:
2273769