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Effective--a database of predicted secreted bacterial proteins
- Jehl, Marc-André, Arnold, Roland, Rattei, Thomas
- Nucleic acids research 2011 v.39 no.suppl_1 pp. D591
- Internet, bacterial proteins, databases, genome, host-pathogen relationships, information retrieval, microsymbionts, nucleic acids, prediction, protein secretion, signal peptide, user interface, virulence
- Protein secretion is a key virulence mechanism of pathogenic and symbiotic bacteria, which makes the investigation of secreted proteins ('effectors') crucial for understanding the molecular bacterium-host interactions. Effective (http://effectors.org) is a database of predicted bacterial secreted proteins, implementing two complementary prediction strategies for protein secretion: the identification of eukaryotic-like protein domains and the recognition of signal peptides in amino acid sequences. The Effective web portal provides user-friendly tools for browsing and retrieving comprehensive precalculated predictions for whole bacterial genomes as well as for the interactive prediction of effectors in user-provided protein sequences.