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BISC: Binary SubComplexes in proteins database

Author:
Juettemann, Thomas, Gerloff, Dietlind L.
Source:
Nucleic acids research 2011 v.39 no.suppl_1 pp. D705
ISSN:
0305-1048
Subject:
Internet, databases, genomics, nucleic acids, protein-protein interactions, proteins, records
Abstract:
Binary subcomplexes in proteins database (BISC) is a new protein-protein interaction (PPI) database linking up the two communities most active in their characterization: structural biology and functional genomics researchers. The BISC resource offers users (i) a structural perspective and related information about binary subcomplexes (i.e. physical direct interactions between proteins) that are either structurally characterized or modellable entries in the main functional genomics PPI databases BioGRID, IntAct and HPRD; (ii) selected web services to further investigate the validity of postulated PPI by inspection of their hypothetical modelled interfaces. Among other uses we envision that this resource can help identify possible false positive PPI in current database records. BISC is freely available at http://bisc.cse.ucsc.edu.
Agid:
2294891