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A Bacterial Protein Targets the BAHD1 Chromatin Complex to Stimulate Type III Interferon Response

Author:
Lebreton, Alice, Lakisic, Goran, Job, Viviana, Fritsch, Lauriane, Tham, To Nam, Camejo, Ana, Matteï, Pierre-Jean, Regnault, Béatrice, Nahori, Marie-Anne, Cabanes, Didier, Gautreau, Alexis, Ait-Si-Ali, Slimane, Dessen, Andréa, Cossart, Pascale, Bierne, Hélène
Source:
Science 2011 v.331 no.6022 pp. 1319-1321
ISSN:
0036-8075
Subject:
Listeria monocytogenes, bacteria, bacterial colonization, bacterial proteins, chromatin, epithelial cells, gene expression, genes, immune response, interferons, listeriosis, mice, pathogens, virulence
Abstract:
Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-λ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1⁺/⁻ mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host.
Agid:
2328115