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Enantioseparation of the New Antifungal Drug Iodiconazole and Structurally Related Triadimenol Analogues by CE with Neutral Cyclodextrin Additives
- Li, Wuhong, Zhao, Liang, Tan, Guangguo, Sheng, Chunquan, Zhang, Xinrong, Zhu, Zhenyu, Zhang, Guoqing, Chai, Yifeng
- Chromatographia 2011 v.73 no.9-10 pp. 1009-1014
- additives, antifungal agents, capillary electrophoresis, chromatography, cyclodextrins, pH, temperature, triadimenol
- Chiral separation of iodiconazole, a new antifungal drug, and 12 new structurally related triadimenol analogues were studied by capillary electrophoresis with seven neutral cyclodextrins. It was found that hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was the most effective chiral selector. Furthermore, the influence of the concentration of HP-γ-CD, buffer pH, buffer concentration, temperature, and applied voltage was investigated, and the method was validated. The study of the analyte structure-enantioseparation relationships showed that substitutions in the side chains had important influences on enantiomeric separation.