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Models for Liquid-Liquid Partition in the System Ethylene Glycol-Organic Solvent and Their Use for Estimating Descriptors for Organic Compounds

Author:
Karunasekara, Thushara, Poole, Colin F.
Source:
Chromatographia 2011 v.73 no.9-10 pp. 941-951
ISSN:
0009-5893
Subject:
chromatography, databases, ethylene dichloride, ethylene glycol, hydrogen bonding, models, partition coefficients, solvents
Abstract:
Partition coefficients for varied compounds were determined for the ethylene glycol-organic solvent biphasic partition system where the organic solvent is n-heptane, 1,2-dichloroethane or isopentyl ether. These partition coefficient databases are analyzed using the solvation parameter model facilitating a quantitative comparison of the ethylene glycol-based partition systems with other totally organic partition systems. Ethylene glycol is a cohesive solvent, reasonably dipolar/polarizable, strongly hydrogen-bond basic, and moderately hydrogen-bond acidic. Ethylene glycol-organic solvent systems offer a complementary approach to other totally organic biphasic partition systems for sample preparation and descriptor measurements of compounds virtually insoluble in water.
Agid:
2335072