Main content area

Synthesis and Application of High Selective Monolithic Fibers Based on Molecularly Imprinted Polymer for SPME of Trace Methamphetamine

Djozan, Djavanshir, Farajzadeh, Mir Ali, Sorouraddin, Saeed Mohammad, Baheri, Tahmineh
Chromatographia 2011 v.73 no.9-10 pp. 975-983
detection limit, gas chromatography, humans, ionization, molecular imprinting, polymerization, polymers, saliva, solid phase microextraction
A monolithic solid-phase microextraction (SPME) fiber was fabricated based on a molecularly imprinted polymer which could be coupled with gas chromatography for extraction, pre-concentration and determination of methamphetamine (MAMP). Methacrylic acid, ethylene glycol dimethacrylate and MAMP play the roles of functional monomer, cross-linker and template, respectively. The effective factors influencing the polymerization and extraction procedures were investigated and will be detailed here. The fabricated fiber was firm, inexpensive, stable, selective and durable which gives it vital importance in SPME. Selectivity of the fabricated fiber in relation to the template in solution containing MAMP, related and unrelated compounds was also investigated. Under the optimum conditions, the calibration plot was linear in the range of 50-3,500 ng mL⁻¹ (r ² = 0.997). The high extraction efficiency was obtained for MAMP giving a detection limit of 14 ng mL⁻¹. The fabricated fiber was successfully applied to SPME of MAMP from human saliva samples followed by gas chromatography-flame ionization detector analysis.