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Modification of T-cell proliferation and interleukin 2 production in mice infected with Trypanosoma cruzi

Author:
Harel-Bellan, A., Joskowicz, M., Fradelizi, D., Eisen, H.
Source:
Proceedings of the National Academy of Sciences of the United States of America 1983 v.80 no.11 pp. 3466-3469
ISSN:
0027-8424
Subject:
Trypanosoma cruzi, immunocompetence, immune response, lymphocytes, immunopathology
Abstract:
Trypanosoma cruzi, mice, acute infection results in severe depression of interleukin 2 (IL-2) production which parallels depressed lymphocyte proliferative response to concanavalin A (Con A), spleen cells from infected mice are able to suppress proliferative response to Con A and (to lesser extent) IL-2 production by spleen cells from normal mice, these and other symptoms of T. cruzi-infected mice are similar to immune dysfunction of autoimmune lpr/lpr mice
Agid:
2349114