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Memory CD8⁺ T cells are gatekeepers of the lymph node draining the site of viral infection

Author:
Xu, Ren-Huan, Fang, Min, Klein-Szanto, Andres, Sigal, Luis J.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.26 pp. 10992-10997
ISSN:
0027-8424
Subject:
CD8-positive T-lymphocytes, Ectromelia virus, antibodies, immunity, lymph nodes, models, vertebrate viruses, viruses
Abstract:
It is uncertain how immunity protects against systemic viral diseases. Here, we demonstrate that in the absence of persistent virus, not only antibodies but also recall responses by long-lived memory CD8⁺ T cells prevent mousepox, a disease caused by ectromelia virus, a close relative of the virus of human smallpox. Moreover, we show that to protect, recall CD8⁺ T cells directly kill targets in the lymph node draining the primary site of infection thus curbing systemic viral spread. Therefore, our work provides the basis for a model where lymph nodes are not just organs where lymphocytes become activated and proliferate but also the sites where a major fight against virus spread takes place.
Agid:
2353080