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An algorithm to generate low-resolution protein tertiary structures from knowledge of secondary structure
- Monge, A., Friesner, R.A., Honig, B.
- Proceedings of the National Academy of Sciences of the United States of America 1994 v.91 no.11 pp. 5027-5029
- proteins, polypeptides, molecular conformation, algorithms, prediction
- An algorithm is described to assemble the three-dimensional fold of a protein starting from its secondary structure. A reduced representation of the polypeptide chain is used together with a crude potential based on pair hydrophobicities. The method is shown to be successful in locating the native topology for two 4-alpha-helix bundles, myohemerythrin and cytochrome b-562.