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The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila

Author:
Zollman, S., Godt, D., Prive, G.G., Couderc, J.L., Laski, F.A.
Source:
Proceedings of the National Academy of Sciences of the United States of America 1994 v.91 no.22 pp. 10717-10721
ISSN:
0027-8424
Subject:
Drosophila melanogaster, multigene family, structural genes, DNA-binding proteins, nucleotide sequences, amino acid sequences, chromosome mapping, embryogenesis, transcription factors
Abstract:
The Drosophila bric a brac protein and the transcriptional regulators encoded by tramtrack and Broad-Complex contain a highly conserved domain of approximately 15 amino acids, which we have called the BTB domain. We have identified six additional Drosophila genes that encode this domain. Five of these genes are developmentally regulated, and one of them appears to be functionally related to bric a brac. The BTB domain defines a gene family with an estimated 40 members in Drosophila. This domain is found primarily at the N terminus of zinc finger proteins and is evolutionarily conserved from Drosophila to mammals.
Agid:
2355359