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Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila
- Dushay, M.S., Asling, B., Hultmark, D.
- Proceedings of the National Academy of Sciences of the United States of America 1996 v.93 no.19 pp. 10343-10347
- Drosophila melanogaster, transcription factors, DNA-binding proteins, nucleotide sequences, amino acid sequences, gene expression, messenger RNA, immune system, immune response, Enterobacter cloacae, embryogenesis, complementary DNA, chromosome mapping, animal proteins, embryo (animal), promoter regions
- NF-kappaB/Rel transcription factors are central regulators of mammalian immunity and are also implicated in the induction of cecropins and other antibacterial peptides in insects. We identified the gene for Relish, a compound Drosophila protein that, like mammalian p105 and p100, contains both a Rel homology domain and an IkappaB-like domain. Relish is strongly induced in infected flies, and it can activate transcription from the Cecropin A1 promoter. A Relish transcript is also detected in early embryos, suggesting that it acts in both immunity and embryogenesis. The presence of a compound Rel protein in Drosophila indicates that similar proteins were likely present in primordial immune systems and may serve unique signaling functions.