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Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

Author:
Coomaraswamy, Janaky, Kilger, Ellen, Wölfing, Heidrun, Schäfer, Claudia, Kaeser, Stephan A., Wegenast-Braun, Bettina M., Hefendehl, Jasmin K., Wolburg, Hartwig, Mazzella, Matthew, Ghiso, Jorge, Goedert, Michel, Akiyama, Haruhiko, Garcia-Sierra, Francisco, Wolfer, David P., Mathews, Paul M., Jucker, Mathias
Source:
Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.17 pp. 7969-7974
ISSN:
0027-8424
Subject:
Alzheimer disease, amyloid, animal models, anxiety, brain, crossing, genetically modified organisms, mice, neurodegenerative diseases, pathophysiology, peptides
Abstract:
Familial Danish dementia (FDD) is a progressive neurodegenerative disease with cerebral deposition of Dan-amyloid (ADan), neuroinflammation, and neurofibrillary tangles, hallmark characteristics remarkably similar to those in Alzheimer's disease (AD). We have generated transgenic (tg) mouse models of familial Danish dementia that exhibit the age-dependent deposition of ADan throughout the brain with associated amyloid angiopathy, microhemorrhage, neuritic dystrophy, and neuroinflammation. Tg mice are impaired in the Morris water maze and exhibit increased anxiety in the open field. When crossed with TauP301S tg mice, ADan accumulation promotes neurofibrillary lesions, in all aspects similar to the Tau lesions observed in crosses between β-amyloid (Aβ)-depositing tg mice and TauP301S tg mice. Although these observations argue for shared mechanisms of downstream pathophysiology for the sequence-unrelated ADan and Aβ peptides, the lack of codeposition of the two peptides in crosses between ADan- and Aβ-depositing mice points also to distinguishing properties of the peptides. Our results support the concept of the amyloid hypothesis for AD and related dementias, and suggest that different proteins prone to amyloid formation can drive strikingly similar pathogenic pathways in the brain.
Agid:
2368687