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An answer to a complex problem: cloning the mouse t-complex responder

Author:
Lyon, Mary F.
Source:
Mammalian genome 2000 v.11 no.10 pp. 817-819
ISSN:
0938-8990
Subject:
genes, heterozygosity, males, meiotic drive, mice
Abstract:
The t-complex is maintained in wild mouse populations by its high transmission (up to 99%) from heterozygous males and provides an example of ``meiotic drive''. Its molecular basis has remained obscure despite long and intensive study. In a major advance, the t-complex responder gene, thought to be the key gene on which several distorters act, has now been cloned.
Agid:
246524