Jump to Main Content
An answer to a complex problem: cloning the mouse t-complex responder
- Lyon, Mary F.
- Mammalian genome 2000 v.11 no.10 pp. 817-819
- genes, heterozygosity, males, meiotic drive, mice
- The t-complex is maintained in wild mouse populations by its high transmission (up to 99%) from heterozygous males and provides an example of ``meiotic drive''. Its molecular basis has remained obscure despite long and intensive study. In a major advance, the t-complex responder gene, thought to be the key gene on which several distorters act, has now been cloned.