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Relationship between use of proton pump inhibitors and IGF system in older subjects

Maggio, Marcello, Lauretani, F., De Vita, F., Butto, V., Cattabiani, C., Masoni, S., Sutti, E., Bondi, G., Dall’Aglio, E., Bandinelli, S., Corsonello, A., Abbatecola, A. M., Lattanzio, F., Ferrucci, L., Ceda, G. P.
The journal of nutrition, health & aging 2014 v.18 no.4 pp. 420-423
C-reactive protein, albumins, blood glucose, body mass index, elderly, energy intake, food intake, insulin-like growth factor I, interleukin-6, liver function, men, physical activity, protein intake, proton pump, women
OBJECTIVES: to investigate the effects of proton pump inhibitors (PPIs) on the insulin-like-growth factor 1(IGF-1) system in the elderly. DESIGN: cross-sectional. SETTING: InCHIANTI study. PARTICIPANTS: 938 older subjects (536 women, 402 men, mean age 75.7±7.4 years). MEASUREMENTS: complete data on age, sex, BMI, liver function, medications, dietary intake, IGF-1, IGF-binding protein-1 and -3 (IGFBP-1, IGFBP-3). RESULTS: Participants were categorized by PPI use, identifying 903 PPI non users and 35 users. After adjusting for age, male PPI users (107.0 ± 69.6 vs 127.1 ± 55.8, p<0.001) and female PPI users (87.6 ± 29.1 vs 107.6 ± 52.3, p=0.03) had lower IGF-1 levels than non-users. IGFBP-1 levels were similar in the two groups in both sexes. In whole population, after adjustment for age and sex, PPI users had lower IGF-1 levels 81.9 [61.1–113.8] than nonusers 110 [77.8–148.6], p=0.02. After further adjustment for BMI, albumin, liver function, C-reactive protein, Interleukin-6, number of medications, ACE-inhibitors use, caloric intake, protein intake, physical activity, glycemia, and IGFBP-1, the use of PPIs remained significantly and negatively associated with IGF-1 levels (β±SE=−19.60±9.83, p=0.045). CONCLUSION: Use of PPIs was independently and negatively associated with IGF-1 levels.