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Relationship between use of proton pump inhibitors and IGF system in older subjects
- Maggio, Marcello, Lauretani, F., De Vita, F., Butto, V., Cattabiani, C., Masoni, S., Sutti, E., Bondi, G., Dall’Aglio, E., Bandinelli, S., Corsonello, A., Abbatecola, A. M., Lattanzio, F., Ferrucci, L., Ceda, G. P.
- The journal of nutrition, health & aging 2014 v.18 no.4 pp. 420-423
- C-reactive protein, albumins, blood glucose, body mass index, elderly, energy intake, food intake, insulin-like growth factor I, interleukin-6, liver function, men, physical activity, protein intake, proton pump, women
- OBJECTIVES: to investigate the effects of proton pump inhibitors (PPIs) on the insulin-like-growth factor 1(IGF-1) system in the elderly. DESIGN: cross-sectional. SETTING: InCHIANTI study. PARTICIPANTS: 938 older subjects (536 women, 402 men, mean age 75.7±7.4 years). MEASUREMENTS: complete data on age, sex, BMI, liver function, medications, dietary intake, IGF-1, IGF-binding protein-1 and -3 (IGFBP-1, IGFBP-3). RESULTS: Participants were categorized by PPI use, identifying 903 PPI non users and 35 users. After adjusting for age, male PPI users (107.0 ± 69.6 vs 127.1 ± 55.8, p<0.001) and female PPI users (87.6 ± 29.1 vs 107.6 ± 52.3, p=0.03) had lower IGF-1 levels than non-users. IGFBP-1 levels were similar in the two groups in both sexes. In whole population, after adjustment for age and sex, PPI users had lower IGF-1 levels 81.9 [61.1–113.8] than nonusers 110 [77.8–148.6], p=0.02. After further adjustment for BMI, albumin, liver function, C-reactive protein, Interleukin-6, number of medications, ACE-inhibitors use, caloric intake, protein intake, physical activity, glycemia, and IGFBP-1, the use of PPIs remained significantly and negatively associated with IGF-1 levels (β±SE=−19.60±9.83, p=0.045). CONCLUSION: Use of PPIs was independently and negatively associated with IGF-1 levels.