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Ternatin, an anti-inflammatory flavonoid, inhibits thioglycolate-elicited rat peritoneal neutrophil accumulation and lps-activated nitric oxide production in murine macrophages
- Rao, V.S.N., Paiva, L.A.F., Souza, M.F., Campos, A.R., Ribeiro, R.A., Brito, G.A.C., Teixeira, M.J., Silveira, E.R.
- Planta medica 2003 v.69 no.9 pp. 851-853
- dexamethasone, flavonoids, lipopolysaccharides, macrophages, mice, neutrophils, nitric oxide, rats
- Ternatin, an anti-inflammatory flavonoid from Egletes viscosa Less., was examined for its possible influence on thioglycolate-elicited neutrophil influx into the rat peritoneal cavity in vivo and nitric oxide production in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages ex vivo. The neutrophil influx induced by thioglycolate was found to be significantly lower in ternatin (25 and 50 mg/kg, s. c.) pre-treated rats with a similar magnitude of inhibition produced by dexamethasone (1 mg/kg, s. c.), a known anti-inflammatory agent. Also, peritoneal macrophages from ternatin (25 mg/kg)-treated mice that were exposed to LPS demonstrated significantly less production of nitric oxide (NO). These results suggest that ternatin exerts its anti-inflammatory action, at least in part, through inhibition of neutrophil migration and modulation of macrophage function.