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Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs
- Wang, Chao, Zhang, Tian-Tai, Du, Guan-Hua, Zhang, Dong-Ming
- Journal of Asian natural products research 2011 v.13 no.9 pp. 817-825
- anti-inflammatory activity, glycosides, in vitro studies, in vivo studies, nitric oxide, structure-activity relationships
- The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure–activity relationships within these compounds were discussed.