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Depsitinuside: a new depside galactoside from an endophytic fungus isolated from Viburnum tinus

Author:
Nazir, Mamona, Sultan, Misbah, Riaz, Naheed, Hafeez, Maria, Hussain, Hidayat, Ahmed, Ishtiaq, Schulz, Barbara, Draeger, Siegfried, Jabbar, Abdul, Krohn, Karsten, Ashraf, Muhammad, Saleem, Muhammad
Source:
Journal of Asian natural products research 2011 v.13 no.11 pp. 1056-1060
ISSN:
1477-2213
Subject:
endophytes, acetylcholinesterase, nuclear magnetic resonance spectroscopy, linoleate 13S-lipoxygenase, chromatography, fungi, mass spectrometry, Viburnum tinus, ergosterol
Abstract:
Chromatographic purification of the extract of an endophytic fungal culture yielded depsitinuside (1), a new phenolic ester together with ergosterol (2) and (22E,24S)-24-methyl-5-α-cholesta-7,22-diene-3β,5,6β-triol (3). The structure of 1 was elucidated based on 1D, 2D NMR spectroscopy and high-resolution mass spectrometry, whereas the known compounds (2 and 3) were identified by ¹H NMR, mass spectrometry, and in comparison with the literature values. Compound 1 was evaluated for its enzyme inhibitory potential against acetylcholinesterase, butyrylcholinesterase and lipoxygenase, and was found inactive (10%–40% inhibition at a concentration of 2 mg/ml).
Agid:
257099