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Chemical constituents from Solidago canadensis with hypolipidemic effects in HFD-fed hamsters

Author:
Huang, Ying, Hao, Yan-Li, Mai, Xiao-Yan
Source:
Journal of Asian natural products research 2013 v.15 no.4 pp. 319-324
ISSN:
1477-2213
Subject:
Solidago canadensis, chemical composition, chemical structure, hamsters, high fat diet, lignans, lipemic effect, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Two new compounds, 8-dehydroxymethylvisanol (1) and 9-O-[3-O-acetyl-β-d-glucopyranosyl]-4-hydroxy-cinnamic acid (4), together with two known lignans, visanol (2) and 9-aldehydevibsanol (3), were isolated from the 80% EtOH extract of Solidago canadensis. The structures of the two new compounds were elucidated on the basis of 1D, 2D NMR, and mass spectral analysis. All the lignans exhibited moderate hypolipidemic activity in high-fat diet-fed hamsters.
Agid:
257340