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Flavone C-glycosides from the flowers of Trollius chinensis and their anti-complementary activity

Author:
Liu, Jiang-Yun, Li, Sheng-Yin, Feng, Jian-Yong, Sun, Yan, Cai, Jin-Na, Sun, Xiao-Fei, Yang, Shi-Lin
Source:
Journal of Asian natural products research 2013 v.15 no.4 pp. 325-331
ISSN:
1477-2213
Subject:
Trollius chinensis, bioassays, chemical structure, complement, electrospray ionization mass spectrometry, flavonoids, flowers, inhibitory concentration 50, nuclear magnetic resonance spectroscopy
Abstract:
Phytochemical investigation of ethanol extract from the flowers of Trollius chinensis Bunge resulted in the isolation of two new flavone C-glycosides (1–2), along with 10 known compounds (3–12). The structures of the new compounds were established as 6‴-(3-hydroxy-3-methylglutaroyl)-2″-O-β-d-galactopyranosyl orientin (1) and 6‴-(3-hydroxy-3-methylglutaroyl)-2″-O-β-d-galactopyranosyl vitexin (2) on the basis of various spectroscopic analysis (including different 1D and 2D NMR spectroscopies, high-resolution electrospray ionization mass spectrometry) and chemical evidences. Bioassay showed that eight flavonoids inhibited complement activation on the classic pathway in vitro, with their IC₅₀ values ranging from 0.88 to 4.02 mM, which may contribute to the applications of the herb in treatment of acute respiratory distress syndrome, etc.
Agid:
257341