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Cytotoxic monacolin analogs from Monascus purpureus-fermented rice

Author:
Liu, Ming-Tao, Wang, A-Li, Sun, Zhen, Li, Jin-Jie, Wu, Xiu-Li, Liu, Yan-Xia, Shang, Xiao-Ya
Source:
Journal of Asian natural products research 2013 v.15 no.6 pp. 600-609
ISSN:
1477-2213
Subject:
Monascus, cytotoxicity, inhibitory concentration 50, monacolins, neoplasm cells, nuclear magnetic resonance spectroscopy, rice, spectral analysis
Abstract:
Two new monacolin analogs, monacolins O (1) and P (2), along with three known analogs, have been isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses as well as chemical method. Both 1 and 2 were tested against five tumor cell lines, and compound 1 exhibited selective cytotoxic activity against A2780 and A549 cell lines, with IC₅₀ values of 3.7 and 8.0 μM, respectively.
Agid:
257362