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Antimalarial activity in Xylocarpus granatum (Koen)

Author:
Lakshmi, Vijai, Srivastava, Shishir, Mishra, Sunil Kumar, Srivastava, Mahendra Nath, Srivastava, Kumkum, Puri, Sunil Kumar
Source:
Natural product research 2012 v.26 no.11 pp. 1012-1015
ISSN:
1478-6427
Subject:
Plasmodium falciparum, Xylocarpus, antimalarials, chloroform, fruits, models, palmitic acid
Abstract:
The antimalarial activity of Xylocarpus granatum fruits and their active constituents gedunin and xyloccensin-I were investigated using an in vitro model in this study. The chloroform fraction of X. granatum fruits was found to show promising antimalarial activity using an in vitro model of Plasmodium falciparum. On purification of the active fraction, four pure compounds were isolated and characterised, namely gedunin, photogedunin, xyloccensin-I and palmitic acid. Out of these only gedunin and xyloccensin-I were found to show activity equivalent to the parent active fraction in vitro model.
Agid:
260622