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In vitro antiviral activities of extracts derived from Daucus maritimus seeds

Author:
Miladi, S., Abid, N., Debarnôt, C., Damak, M., Canard, B., Aouni, M., Selmi, B.
Source:
Natural product research 2012 v.26 no.11 pp. 1027-1032
ISSN:
1478-6427
Subject:
Daucus, Dengue virus, Hepatitis C virus, Human immunodeficiency virus, RNA, RNA-directed DNA polymerase, West Nile virus, antiviral properties, ethyl acetate, inhibitory concentration 50, seeds
Abstract:
The antiviral activities of extracts from Daucus maritimus seeds were investigated against the reverse transcriptase of human immunodeficiency virus (HIV) type 1 and a panel of RNA-dependent RNA polymerases of dengue virus, West Nile virus (WNV) and hepatitis C virus (HCV). The extracts showed moderate to potent inhibition rates against the four viral polymerases. The ethyl acetate extract exhibited a potent inhibitory effect against WNV's RdRp, with an IC₅₀ value of 8 µg mL⁻¹. The F₂ fraction exhibited potent inhibitory activity against WNV and HCV's RdRps, with IC₅₀ values 1 and 5 µg mL⁻¹, respectively. The P₂ fraction also showed potent inhibitory effects on WNV and HCV's RdRps, with IC₅₀ values 2.7 and 4 µg mL⁻¹, respectively. The results suggest that these extracts are candidates for the development of new anti-WNV RpDp and anti-HCV RpDp agents.
Agid:
260629