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Anti-inflammatory activity of Gentiana striata Maxim.

Author:
Cao, Feihua, Shao, Hao, Li, Qiang, Li, Jinrong, Li, Wenqun, Li, Chong
Source:
Natural product research 2012 v.26 no.11 pp. 1038-1044
ISSN:
1478-6427
Subject:
Gentiana, anti-inflammatory activity, edema, ethyl acetate, feet, mechanism of action, nitric oxide, prostaglandins, rats, rheumatoid arthritis
Abstract:
The anti-inflammatory activity and the mechanism of action of Gentiana striata Maxim. has been investigated. The most active phase, the ethyl acetate extract of Gentiana striata Maxim. (EGS), displayed potent inhibitory activity on feet oedema of rheumatoid arthritis (RA) inflicted rats. This anti-inflammatory activity might be partly based on the notable reduction of prostaglandin E2 (PGE₂) and nitric oxide (NO) levels. Six further compounds isolated from EGS have previously been reported as having anti-inflammatory activity.
Agid:
260631