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Antidiarrhoeal and bronchodilatory potential of Valeriana wallichii

Author:
Khan, Arif-ullah, Gilani, Anwarul Hassan
Source:
Natural product research 2012 v.26 no.11 pp. 1045-1049
ISSN:
1478-6427
Subject:
Valeriana jatamansi, asthma, diarrhea, digestive system, glibenclamide, guinea pigs, mice, potassium, potassium channels
Abstract:
This study describes the antidiarrhoeal and bronchodilatory activities of Valeriana wallichii D.C. (Valerianaceae). The crude extract of V. wallichii (Vw.Cr) caused inhibition of castor oil-induced diarrhoea in mice at 300–600 mg kg⁻¹. In guinea-pig trachea, Vw.Cr concentration dependently (0.03–3.0 mg mL⁻¹) relaxed the low K⁺ (25 mM)-induced contractions, with a mild effect on the contractions induced by high K⁺ (80 mM). In the presence of glibenclamide, the relaxation of low K⁺-induced contractions was prevented. Similarly, cromakalim caused glibenclamide-sensitive inhibition of low K⁺, without any effect on high K⁺. These results indicate that V. wallichii exhibits antidiarrhoeal and bronchodilatory activities, possibly through K⁺ channel activation, and thus reveal its medicinal usefulness in hyperactive gut and airway disorders such as diarrhoea and asthma.
Agid:
260632