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Comparison of Tamoxifen with Edible Seaweed (Eucheuma cottonii L.) Extract in Suppressing Breast Tumor

Author:
Shamsabadi, Fatemeh T., Khoddami, Ali, Fard, Samaneh Ghasemi, Abdullah, Rasedee, Othman, Hemn Hassan, Mohamed, Suhaila
Source:
Nutrition and cancer 2013 v.65 no.2 pp. 255-262
ISSN:
1532-7914
Subject:
Eucheuma, anticarcinogenic activity, antioxidants, body weight, breast neoplasms, edible seaweed, erythrocytes, ethanol, glutathione, hepatotoxicity, kidneys, liver, macroalgae, malondialdehyde, mammary glands, mammary neoplasms (animal), nutrients, oral administration, polyphenols, rats, subcutaneous injection, superoxide dismutase, tamoxifen
Abstract:
The tropical edible red seaweed (Eucheuma cottonii L.) is rich in nutrients and polyphenolic compounds that may suppress cancer through its antioxidant and antiproliferative properties. The study reports on rat mammary tumor suppression and tissue antioxidant status modulation by E. cottonii ethanol extract (ECE). The effect of orally administered ECE (100 mg/kg body-weight) was compared with that of tamoxifen (10 mg/kg body-weight). Rat was induced to develop mammary tumor with subcutaneous injection of LA-7 cells (6 × 10⁶ cells/rat). The ECE was more effective than tamoxifen in suppressing tumor growth (27%), improving tissues (plasma, liver, and kidney) malondialdehyde concentrations, superoxide dismutase activity and erythrocyte glutathione concentrations (P < 0.05). Unlike tamoxifen, the ECE displayed little toxicity to the liver and kidneys. The ECE exhibited strong anticancer effect with enzyme modulating properties, suggesting its potential as a suppressing agent for mammary gland tumor.
Agid:
263393