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Pathological changes in rats fed the Crambe meal-glucosinolate hydrolytic products, 2S-1-cyano-2-hydroxy-3,4-epithiobutanes (erythro and threo) for 90 days
- Gould, D.H., Gumbmann, M.R., Daxenbichler, M.E.
- Food and cosmetics toxicology 1980 v.18 no.6 pp. 619
- Crambe abyssinica, seeds, seed extracts, glucosinolates, antinutritional factors, Brassica, rats, weanlings, animal models, nutrient intake, enzymatic hydrolysis, dosage, feed conversion, animal growth, blood serum, alkaline phosphatase, bilirubin, transaminases, alanine transaminase, ornithine carbamoyltransferase, renal function, hypertrophy, hepatotoxicity, lesions (animal), hyperplasia, biliary tract diseases, liver cirrhosis, nephrotoxicity
- Groups of 6 weanling rats were given 2S-1-cyano-2-hydroxy-3,4-epithiobutanes (erythro and threo), isolated from the seed of Crambe abyssinica, 0.75, 150 or 300 mu g/g diet for 90 days. The last 2 groups grew poorly and had increased serum contents of alkaline phosphatase, total bilirubin, aspartate aminotransferase, alanine aminotransferase and ornithine carbamolytransferase. The severity and occurrence of renal and hepatic lesions were dose-dependent. There was hypertrophy of proximal tubular epithelial cells with prominent karyomegaly. Hepatic lesions consisted primarily of megalocytosis of the hepatocytes and bile-duct hyperplasia with disruption of the normal hepatic architecture. Half of the rats in the last group had karyomegaly of pancreatic acinar cells.