PubAg

Main content area

Involvement of Listeria monocytogenes Phosphatidylinositol-Specific Phospholipase C and Host Protein Kinase C in Permeabilization of the Macrophage Phagosome

Author:
Poussin, Mathilde A., Goldfine, Howard
Source:
Infection and immunity 2005 v.73 no.7 pp. 4410-4413
ISSN:
0019-9567
Subject:
Listeria monocytogenes, bacteria, macrophages, phospholipase C, protein kinase C
Abstract:
We have previously shown that phosphatidylinositol-specific phospholipase C (PI-PLC) produced by Listeria monocytogenes activates a host protein kinase C (PKC) cascade which promotes escape of the bacterium from a macrophage-like cell phagosome. Here, we provide evidence linking bacterial PI-PLC and host PKC {szligbeta} to phagosome permeabilization, which precedes escape.
Agid:
266306