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Identification of Variant-Specific Surface Proteins in Giardia muris Trophozoites
- Ropolo, Andrea S., Saura, Alicia, Carranza, Pedro G., Lujan, Hugo D.
- Infection and immunity 2005 v.73 no.8 pp. 5208-5211
- Giardia lamblia, Giardia muris, antigenic variation, immune response, parasites, rodents, surface proteins, trophozoites
- Giardia lamblia undergoes antigenic variation, a process that might allow the parasite to evade the host's immune response and adapt to different environments. Here we show that Giardia muris, a related species that naturally infects rodents, possesses multiple variant-specific surface proteins (VSPs) and expresses VSPs on its surface, suggesting that it undergoes antigenic variation similar to that of G. lamblia.