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Listeria monocytogenes 10403S HtrA Is Necessary for Resistance to Cellular Stress and Virulence
- Wilson, Rebecca L., Brown, Lindsay L., Kirkwood-Watts, Dana, Warren, Travis K., Lund, S. Amanda, King, David S., Jones, Kevin F., Hruby, Dennis E.
- Infection and immunity 2006 v.74 no.1 pp. 765-768
- Listeria monocytogenes, biofilm, heat stress, mice, mutants, serine proteinases, virulence
- The HtrA serine protease has been shown to be essential for bacterial virulence and for survival after exposure to many types of environmental and cellular stresses. A Listeria monocytogenes 10403S htrA mutant was found to be sensitive to oxidative and puromycin-induced stress at high temperatures, showed a reduced ability to form biofilms, and was attenuated for virulence in mice.