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Immunization with Persistent Attenuated [Delta]lpg2 Leishmania major Parasites Requires Adjuvant To Provide Protective Immunity in C57BL/6 Mice

Author:
Kébai̊er, Chahnaz, Uzonna, Jude E., Beverley, Stephen M., Scott, Phillip
Source:
Infection and immunity 2006 v.74 no.1 pp. 777-780
ISSN:
0019-9567
Subject:
Leishmania major, immunity, immunization, mice, oligodeoxyribonucleotides, parasites
Abstract:
Leishmania major parasites lacking the GDP-mannose transporter, termed [Delta]lpg2 parasites, fail to induce disease in mice but persist long-term. We previously found that [Delta]lpg2 organisms protect BALB/c mice from virulent L. major challenge. In contrast, we report here that [Delta]lpg2 parasites induce protective immunity in C57BL/6 mice only when administered with CpG-containing oligodeoxynucleotides, indicating that parasite persistence alone is not sufficient to maintain protective immunity to L. major.
Agid:
267254